|
rs750814369
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the variant genotypes of p21 Ser31Arg and p27 C-79T were individually associated with a significantly increased risk of HCC, but no associations were observed for other variant genotypes.
|
23034899 |
2013 |
|
rs9261204
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found consistently significant associations between the ZNRD1-AS1 rs6940552 and rs9261204 SNPs with an increased risk of HCC (additive genetic model: adjusted OR = 1.16, 95% CI = 1.03-1.32 for rs6940552; adjusted OR =1.20, 95% CI = 1.06-1.35 for rs9261204) and found a borderline association between rs3757328 and HCC risk.
|
27286450 |
2016 |
|
rs9261204
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We designed a case-control study of 1300 HBV-positive HCC patients, 1344 HBV persistent carriers and, 1344 HBV natural clearance subjects to test the associations of three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and, rs9261204) in ZNRD1-AS1 with the risk of both chronic HBV infection and HCC.
|
25110835 |
2015 |
|
rs6940552
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We designed a case-control study of 1300 HBV-positive HCC patients, 1344 HBV persistent carriers and, 1344 HBV natural clearance subjects to test the associations of three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and, rs9261204) in ZNRD1-AS1 with the risk of both chronic HBV infection and HCC.
|
25110835 |
2015 |
|
rs6940552
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found consistently significant associations between the ZNRD1-AS1 rs6940552 and rs9261204 SNPs with an increased risk of HCC (additive genetic model: adjusted OR = 1.16, 95% CI = 1.03-1.32 for rs6940552; adjusted OR =1.20, 95% CI = 1.06-1.35 for rs9261204) and found a borderline association between rs3757328 and HCC risk.
|
27286450 |
2016 |
|
rs3757328
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found consistently significant associations between the ZNRD1-AS1 rs6940552 and rs9261204 SNPs with an increased risk of HCC (additive genetic model: adjusted OR = 1.16, 95% CI = 1.03-1.32 for rs6940552; adjusted OR =1.20, 95% CI = 1.06-1.35 for rs9261204) and found a borderline association between rs3757328 and HCC risk.
|
27286450 |
2016 |
|
rs3757328
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Logistic regression analyses in additive genetic model showed that variant alleles of all the three SNPs increased host HCC risk, whereas variant allele of rs3757328 was associated with HBV clearance.
|
25110835 |
2015 |
|
rs5751129
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Firstly, the associations of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter A-31G (rs132770), and intron-3 (rs132774) polymorphisms with HCC risk in this Taiwanese population were evaluated.
|
23393345 |
2013 |
|
rs2267437
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Firstly, the associations of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter A-31G (rs132770), and intron-3 (rs132774) polymorphisms with HCC risk in this Taiwanese population were evaluated.
|
23393345 |
2013 |
|
rs132770
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Firstly, the associations of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter A-31G (rs132770), and intron-3 (rs132774) polymorphisms with HCC risk in this Taiwanese population were evaluated.
|
23393345 |
2013 |
|
rs132774
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Firstly, the associations of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter A-31G (rs132770), and intron-3 (rs132774) polymorphisms with HCC risk in this Taiwanese population were evaluated.
|
23393345 |
2013 |
|
rs9288516
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that a significantly reduced risk for HCC was associated with XRCC5 rs16855458 [odds ratio (OR)=0.59; 95% confidence interval (CI)=0.43-0.81; CA+AA versus CC] and a significantly increased risk for HCC was associated with XRCC5 rs9288516 (OR=2.02; 95% CI=1.42-2.86; TA+AA versus TT) even after Bonferroni correction (Pcorrected=0.026 and 0.002, respectively).
|
21304054 |
2011 |
|
rs80309960
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the role of genetic polymorphisms at XRCC4 codon 247 (rs3734091, XRCC4P) and XRCC5 codon 180 (rs80309960, XRCC5P) in liver cancer (hepatocellular carcinoma) caused by aflatoxin B1 (AFB1).
|
23788213 |
2013 |
|
rs16855458
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that a significantly reduced risk for HCC was associated with XRCC5 rs16855458 [odds ratio (OR)=0.59; 95% confidence interval (CI)=0.43-0.81; CA+AA versus CC] and a significantly increased risk for HCC was associated with XRCC5 rs9288516 (OR=2.02; 95% CI=1.42-2.86; TA+AA versus TT) even after Bonferroni correction (Pcorrected=0.026 and 0.002, respectively).
|
21304054 |
2011 |
|
rs1805377
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNP of XRCC4 rs1805377 was significantly associated with decreased risk of HCC development (OR, 0.592; p=0.028) and improved overall survival of patients with HCC (median survival time (MST) of 48, 72, and 89 months for the AA, AG, and GG genotypes, respectively; p=0.044).
|
22659345 |
2012 |
|
rs1805377
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
With TaqMan real-time PCR, the results showed that no significant association between XRCC4 (rs1</span>805377) and ATF6 (rs2070150) and risk of HCC in the Thai population.
|
26925648 |
2016 |
|
rs3734091
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the role of genetic polymorphisms at XRCC4 codon 247 (rs3734091, XRCC4P) and XRCC5 codon 180 (rs80309960, XRCC5P) in liver cancer (hepatocellular carcinoma) caused by aflatoxin B1 (AFB1).
|
23788213 |
2013 |
|
rs28383151
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These individuals with the genotypes of rs283</span>83151 A alleles (rs28383151-GA/AA), compared with the homozygote of rs28383151 G alleles (rs28383151-GG), faced increasing risk of HCC (odds ratio [OR]: 2.17; 95% confidence interval: 1.77-2.67).
|
23390017 |
2013 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
More rigorous association studies are needed to verify the involvement of XRCC1 Arg280His polymorphism in HCC susceptibility.
|
22919255 |
2012 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the rs25489 and rs1799782 polymorphisms were associated with increased risk of HCC.
|
31478224 |
2020 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In overall analyses, the minor alleles of four variants, Arg280His (odds ratio, 95% confidence interval, P: 1.37, 1.13-1.66, 0.001), Thr241Met (1.93, 1.17-3.20, 0.011), Asp312Asn (1.22, 1.08-1.38, 0.001) and Lys751Gln (1.42, 1.02-1.97, 0.038), were associated with the significant risk for hepatocellular carcinoma.
|
27306318 |
2016 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no association between the risk of HCC development and the XRCC1 Arg280His or XRCC1 Arg399Gln genotypes.
|
29935355 |
2018 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The XRCC1 Arg280His gene polymorphism and hepatocellular carcinoma risk: a meta-analysis.
|
23679314 |
2013 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, there was no association between Arg194Trp or Arg280His and the risk of HCC.
|
30408066 |
2018 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interestingly, the risk for HCC was further enhanced by 35.96 (95% CI = 11.64-110.91; P < 0.001) and 5.28 times (95% CI = 2.81-9.09; P < 0.001) when the genotype Arg280His was found in association with Arg194Trp and Arg399Gln, respectively.
|
19194663 |
2009 |